flowchart changes updated
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mukesh13
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import React from 'react';
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const ExomeMitoTitle = () => {
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return (
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<section
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className="relative bg-cover bg-center py-6 h-24"
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style={{ backgroundImage: "url('/images/bredcrumb.jpg')" }}
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>
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{/* Breadcrumb */}
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<div className="relative z-10 mb-1 -mt-3">
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<div className="container mx-auto max-w-none px-4">
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<nav className="flex items-center space-x-2 text-sm">
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<a href="/" className="text-white hover:text-yellow-400 underline">Home</a>
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<span className="text-white">
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<svg className="w-3 h-3" fill="currentColor" viewBox="0 0 20 20">
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<path fillRule="evenodd" d="M7.293 14.707a1 1 0 010-1.414L10.586 10 7.293 6.707a1 1 0 011.414-1.414l4 4a1 1 0 010 1.414l-4 4a1 1 0 01-1.414 0z" clipRule="evenodd" />
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</svg>
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</span>
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<a href="/health" className="text-white hover:text-yellow-400 underline">Health</a>
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<span className="text-white">
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<svg className="w-3 h-3" fill="currentColor" viewBox="0 0 20 20">
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<path fillRule="evenodd" d="M7.293 14.707a1 1 0 010-1.414L10.586 10 7.293 6.707a1 1 0 011.414-1.414l4 4a1 1 0 010 1.414l-4 4a1 1 0 01-1.414 0z" clipRule="evenodd" />
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</svg>
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</span>
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<a href="/health/rare-disorders" className="text-white hover:text-yellow-400 underline">Rare Disorder</a>
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<span className="text-white">
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<svg className="w-3 h-3" fill="currentColor" viewBox="0 0 20 20">
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<path fillRule="evenodd" d="M7.293 14.707a1 1 0 010-1.414L10.586 10 7.293 6.707a1 1 0 011.414-1.414l4 4a1 1 0 010 1.414l-4 4a1 1 0 01-1.414 0z" clipRule="evenodd" />
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</svg>
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</span>
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<span className="text-white">Operify ExomeMito</span>
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</nav>
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</div>
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</div>
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{/* Page Title */}
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<div className="relative z-10 text-center -mt-2">
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<h1 className="text-4xl md:text-4xl font-bold text-white mb-2">
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Operify ExomeMito
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</h1>
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<div className="w-16 h-1 bg-yellow-400 mx-auto"></div>
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</div>
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</section>
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);
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};
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export default ExomeMitoTitle;
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export default function OperifyExomeMito() {
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const features = [
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{ title: "High Mean Target Depth", desc: "≥100X coverage for reliable detection." },
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{ title: "High Base Quality", desc: "≥90% of bases with Q30 score." },
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{ title: "Scope of Test", desc: "Covers SNVs/Indels, CNVs in nuclear and mitochondrial genome." },
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{ title: "Uniparental Disomy", desc: "Detects regions important in rare recessive conditions." },
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{ title: "Homologous Gene Analysis", desc: "Includes SMN1, SMN2, DMD." },
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{ title: "Aneuploidy & Ploidy Estimation", desc: "Detects abnormal chromosome numbers and sex karyotype." },
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{ title: "Reanalysis & Reclassification", desc: "Updates based on latest scientific knowledge." }
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];
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const genomeCoverage = [
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{ genome: "Nuclear Genome", coverage: "Protein-coding regions of ~20000 genes" },
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{ genome: "Mitochondrial genome", coverage: "37 genes" }
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];
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const points = [
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"The Operify ExomeMito Panel offers a unified solution by integrating whole exome sequencing with complete mitochondrial genome analysis—addressing both nuclear and mitochondrial causes of disease.",
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"This combined approach is especially valuable in diagnosing complex, multisystemic, and rare disorders, where variants may exist across both genomes.",
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"Mitochondrial disorders, though individually rare, are clinically significant, affecting approximately 1 in 5,000 individuals and often missed in standard testing.",
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"Studies show that adding mitochondrial sequencing to exome testing increases diagnostic yield by up to 20%, offering greater clarity and clinical confidence. (PMID: 30369941)",
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"While screening for rare genetic disorders, it's essential not to overlook the rarest among them-mitochondrial disorders, which occur in approximately 1 in 5,000 individuals. Although individually rare, their cumulative impact is significant in the context of rare disease diagnostics. Multiple studies have demonstrated a substantial increase in diagnostic yield—up to 20%—when mitochondrial genome sequencing is performed alongside whole exome sequencing. Reference: PMID: 30369941"
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];
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return (
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<section className="mx-auto px-8 pt-10">
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<h2 className="text-3xl font-bold text-teal-700 pb-2 mb-4">Operify ExomeMito</h2>
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<h3 className="text-xl font-semibold text-gray-700 mb-4">Boost diagnostic yield with Exome + Mito Sequencing</h3>
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<div className="mb-6">
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<ul className="space-y-4">
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{points.map((point, idx) => (
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<li key={idx} className="flex items-start">
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<span
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className="w-2 h-2 rounded-full mt-2 mr-3 flex-shrink-0"
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style={{backgroundColor: '#faae31'}}
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></span>
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<p className="text-gray-600 leading-relaxed text-base text-justify">
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{point}
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</p>
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</li>
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))}
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</ul>
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</div>
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<div className="mb-8">
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<h3 className="text-2xl font-semibold text-teal-700 mb-4">Genome Coverage</h3>
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<div className="overflow-x-auto">
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<table className="w-full border-collapse border border-gray-300 rounded-lg">
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<thead>
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<tr className="bg-teal-50">
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<th className="border border-gray-300 px-3 py-2 text-left font-semibold text-teal-700">Genome</th>
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<th className="border border-gray-300 px-3 py-2 text-left font-semibold text-teal-700">Coverage</th>
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</tr>
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</thead>
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<tbody>
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{genomeCoverage.map((item, idx) => (
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<tr key={idx} className="hover:bg-teal-50">
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<td className="border border-gray-300 px-6 py-3 text-gray-700 font-medium">{item.genome}</td>
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<td className="border border-gray-300 px-6 py-3 text-gray-600">{item.coverage}</td>
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</tr>
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))}
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</tbody>
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</table>
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</div>
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</div>
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<h3 className="text-2xl font-semibold text-teal-700 mb-4">Key Features</h3>
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<div className="overflow-x-auto">
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<table className="w-full border-collapse border border-gray-300 rounded-lg">
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<thead>
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<tr className="bg-teal-50">
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<th className="border border-gray-300 px-3 py-2 text-left font-semibold text-teal-700">Feature</th>
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<th className="border border-gray-300 px-3 py-2 text-left font-semibold text-teal-700">Description</th>
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</tr>
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</thead>
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<tbody>
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{features.map((feature, idx) => (
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<tr key={idx} className="hover:bg-teal-50">
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<td className="border border-gray-300 px-6 py-3 text-gray-700 font-medium">{feature.title}</td>
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<td className="border border-gray-300 px-6 py-3 text-gray-600">{feature.desc}</td>
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</tr>
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))}
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</tbody>
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</table>
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</div>
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</section>
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);
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}
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