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// app/dna-sequencing/enrichment-sequencing/whole-exome/components/ExomeAdvantages.jsx
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import AdvantagesLayout from '../../../../components/shared/AdvantagesLayout';
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const ExomeAdvantages = () => {
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const advantageItems = [
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"Cost-effective as compared to Whole Genome Sequencing (WGS), making it accessible to a broader range of researchers and clinicians.",
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"WES offers extensive sequencing of exonic regions, improving the detection of single-nucleotide variants (SNVs), copy number variants (CNVs), and insertions/deletions (InDels) with a sensitivity comparable to WGS, ensuring high accuracy in identifying genetic variants.",
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"WES generates a smaller data set compared to WGS, facilitating faster and easier data analysis, which can expedite research and diagnostic processes.",
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"WES is widely used in both medical and agricultural fields, supporting advancements in disease diagnosis, personalized medicine, and crop improvement. Provides a comprehensive, high-resolution view of the genome, surpassing the coverage offered by targeted sequencing."
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];
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return (
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<AdvantagesLayout
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title="Advantages of Whole Exome Sequencing"
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advantageItems={advantageItems}
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/>
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);
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};
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export default ExomeAdvantages;
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// app/dna-sequencing/enrichment-sequencing/whole-exome/components/ExomeApplications.jsx
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import ApplicationsLayout from '../../../../components/shared/ApplicationsLayout';
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const ExomeApplications = () => {
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const applicationItems = [
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"Genetic Disorder Diagnosis- Identifies genetic mutations associated with rare and inherited disorders by focusing on the exonic regions where most disease-related variants occur. This enables accurate diagnosis and personalized treatment plans.",
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"Cancer Research- Detects somatic mutations in cancer genomes, providing insights into tumor biology, identifying potential biomarkers for early detection, and guiding targeted therapies for more effective treatment.",
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"Drug Development- Assists in the discovery of new drug targets and the development of precision medicine by revealing the genetic underpinnings of diseases and how genetic variations affect drug responses.",
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"Population Genetics- Explores genetic variations in diverse populations to understand genetic diversity, evolutionary processes, and the genetic basis of complex traits and diseases, aiding in public health and epidemiological studies.",
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"Functional Genomics- Provides insights into gene function and regulation by identifying coding mutations that impact protein function, contributing to our understanding of gene-disease relationships and mechanisms of gene action.",
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"Plant Genomics- Supports crop improvement and plant breeding programs by revealing the genetic basis of desirable traits and enhancing the understanding of plant genomes."
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];
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return (
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<ApplicationsLayout
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title="Applications of Whole Exome Sequencing"
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applicationItems={applicationItems}
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/>
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);
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};
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export default ExomeApplications;
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// app/dna-sequencing/enrichment-sequencing/whole-exome/components/ExomeIntroduction.jsx
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import IntroductionLayout from '../../../../components/shared/IntroductionLayout';
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const ExomeIntroduction = () => {
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const contentItems = [
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"Whole Exome Sequencing (WES) is sequencing of only protein-coding regions (<2% of the genome, also known as exome), which accounts for 80-85% of disease-related variants.",
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"The workflow involves DNA isolation, fragmentation, capturing exonic regions, and sequencing to generate millions of short reads. In the bioinformatics analysis, these reads undergo alignment to a reference genome, followed by the variant calling (SNVs, Indels) and data analysis.",
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"Pinpoints potential disease-causing mutations, providing valuable insights for population genetics, genetic disease research, and cancer studies.",
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"Extensively utilized in diagnostic setting to detect clinically relevant genomic alterations associated with phenotype of the patient."
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];
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return (
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<IntroductionLayout
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title="Introduction and Workflow"
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contentItems={contentItems}
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imageUrl="/images/dna.jpg"
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imageAlt="DNA Structure"
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useParagraphs={true}
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/>
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);
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};
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export default ExomeIntroduction;
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// app/dna-sequencing/enrichment-sequencing/whole-exome/components/ExomeSpecifications.jsx
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import Link from 'next/link';
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import SpecificationsLayout from '../../../../components/shared/SpecificationsLayout';
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const ExomeSpecifications = () => {
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const specificationItems = [
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{
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icon: "/images/homepage-2/NGS-Icons-45.svg",
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title: "Sample Requirement",
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renderContent: () => (
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<div>
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<div className="mb-3">
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<strong>• Genomic DNA</strong>
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</div>
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<div className="mb-3">
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<strong>• Cultivated cells, Blood, tissues, Fresh Frozen, FFPE</strong>
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<span className="block text-sm text-gray-500 mt-1">
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(formalin-fixed paraffin-embedded)
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</span>
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</div>
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<div className="mt-4 text-sm">
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<strong>
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Please refer to{" "}
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<Link href="/sample-submission-guideline" className="text-teal-600 underline hover:text-teal-700">
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sample submission guidelines
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</Link>
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{" "}or{" "}
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<Link href="/contact-us" className="text-teal-600 underline hover:text-teal-700">
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Contact Us!
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</Link>
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</strong>
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</div>
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</div>
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)
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},
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{
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icon: "/images/homepage-1/service/Advantages-NGS-Icons-20.svg",
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title: "Sequencing Platform",
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content: "Illumina NovaSeq 6000/ NovaSeq X"
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},
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{
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icon: "/images/service/social-support.png",
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title: "Deliverables",
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renderContent: () => (
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<ul className="list-disc pl-5 space-y-2 text-gray-600 text-start">
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<li>The original sequencing data</li>
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<li>Experimental results</li>
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<li>Bioinformatics and Data Analysis Report</li>
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<li>Details in Whole Exome Sequencing (customizable)</li>
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</ul>
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)
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}
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];
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return (
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<SpecificationsLayout
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title="Service Specifications"
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specificationItems={specificationItems}
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/>
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);
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};
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export default ExomeSpecifications;
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