const LongReadComparison = () => { const comparisonData = [ { category: "Read Length", illumina: "Paired-end 150 bp or 250bp\nHighly accurate (> 99.9%) while Limited to ~500bp", pacbio: "Average ≥ 15 kb\nbp to kb", nanopore: "Average > 17 kb\nKb to Mb" }, { category: "Variant Calling", illumina: "Accurately detect the SNVs and InDels\nWhile Lower accuracy on the complex SVs detection", pacbio: "Long Read Length with High Accuracy: Good coverage of highly repetition and complexity area\nDetect SVs with high precision", nanopore: "Long Read Length with High Accuracy: Good coverage of highly repetition and complexity area\nDetect SVs with high precision" }, { category: "Amplification/GC Bias", illumina: "PCR for cluster generation:\n1.Clonally amplified templates masquerade as variants\n2.Underrepresentation of AT-rich and GC-rich regions", pacbio: "NO GC Bias & Amplification Bias\nPCR-free to allow a uniform coverage and High Contiguity", nanopore: "NO GC Bias & Amplification Bias\nPCR-free to allow a uniform coverage and High Contiguity" }, { category: "Machine Errors", illumina: "Signal Decay and Dephasing:\nGradual consumption of reagent\nSeq error rate increases with the length of reads", pacbio: "Relaxed requirement for cycle efficiency", nanopore: "Relaxed requirement for cycle efficiency" }, { category: "DNA Methylation Detection", illumina: "WGBS or RRBS is required and limited on detection of CpG, CHH, CHG", pacbio: "Simultaneous Epigenetic Characterization\nDiverse DNA methylation types: CpG, CHH, CHG, 6mA, 4mC, 5hmc", nanopore: "Simultaneous Epigenetic Characterization\nDiverse DNA methylation types: CpG, CHH, CHG, 6mA, 4mC, 5hmc" } ]; const formatContent = (content, isHighlighted = false) => { if (content.includes("Long Read Length")) { return (
Long Read Length with High Accuracy {content.replace("Long Read Length with High Accuracy", "")}
); } else if (content.includes("NO GC Bias")) { return (
NO GC Bias & Amplification Bias {content.replace("NO GC Bias & Amplification Bias", "")}
); } else if (content.includes("Simultaneous")) { return (
Simultaneous Epigenetic Characterization {content.replace("Simultaneous Epigenetic Characterization", "")}
); } return content; }; return (

Comparison of Sequencers

{/* Original Image Section */}
Long Read Comparison Chart
{/* Detailed Comparison Table Section */}

Comparison and specification of sequencing platforms between short-read and long-read sequencing on WGS

{/* Mobile Card Layout (hidden on desktop) */}
{/* Mobile Table Header */}
Platform Types
Illumina NovaSeq 6000
PacBio Sequel II/IIe
Nanopore PromethION
{comparisonData.map((row, index) => (

{row.category}

Illumina NovaSeq 6000
{row.illumina}
PacBio Sequel II/IIe
{formatContent(row.pacbio)}
Nanopore PromethION
{formatContent(row.nanopore)}
))}
{/* Desktop Table Layout (hidden on mobile) */}
{comparisonData.map((row, index) => ( ))}
Platform Types Illumina NovaSeq 6000 PacBio Sequel II/IIe Nanopore PromethION
{row.category}
{row.illumina}
{formatContent(row.pacbio)}
{formatContent(row.nanopore)}
{/* Right side - Key Highlights */}

Key Technology Highlights

Oxford Nanopore

  • • Real-time sequencing via protein nanopores
  • • Portable devices for field diagnostics
  • • Direct base modification detection

PacBio SMRT

  • • Hi-Fi reads with 99.9% accuracy
  • • Excellent for complex genomes
  • • Haplotype resolution in polyploids

Illumina

  • • High accuracy for SNVs and InDels
  • • Cost-effective for large studies
  • • Mature bioinformatics tools
); }; export default LongReadComparison;