const LongReadComparison = () => { const comparisonData = [ { category: "Read Length", illumina: "Paired-end 150 bp or 250bp\nHighly accurate (> 99.9%) while Limited to ~500bp", pacbio: "Average ≥ 15 kb\nbp to kb", nanopore: "Average > 17 kb\nKb to Mb" }, { category: "Variant Calling", illumina: "Accurately detect the SNVs and InDels\nWhile Lower accuracy on the complex SVs detection", pacbio: "Long Read Length with High Accuracy: Good coverage of highly repetition and complexity area\nDetect SVs with high precision", nanopore: "Long Read Length with High Accuracy: Good coverage of highly repetition and complexity area\nDetect SVs with high precision" }, { category: "Amplification/GC Bias", illumina: "PCR for cluster generation:\n1.Clonally amplified templates masquerade as variants\n2.Underrepresentation of AT-rich and GC-rich regions", pacbio: "NO GC Bias & Amplification Bias\nPCR-free to allow a uniform coverage and High Contiguity", nanopore: "NO GC Bias & Amplification Bias\nPCR-free to allow a uniform coverage and High Contiguity" }, { category: "Machine Errors", illumina: "Signal Decay and Dephasing:\nGradual consumption of reagent\nSeq error rate increases with the length of reads", pacbio: "Relaxed requirement for cycle efficiency", nanopore: "Relaxed requirement for cycle efficiency" }, { category: "DNA Methylation Detection", illumina: "WGBS or RRBS is required and limited on detection of CpG, CHH, CHG", pacbio: "Simultaneous Epigenetic Characterization\nDiverse DNA methylation types: CpG, CHH, CHG, 6mA, 4mC, 5hmc", nanopore: "Simultaneous Epigenetic Characterization\nDiverse DNA methylation types: CpG, CHH, CHG, 6mA, 4mC, 5hmc" } ]; const formatContent = (content, isHighlighted = false) => { if (content.includes("Long Read Length")) { return (
| Platform Types | Illumina NovaSeq 6000 | PacBio Sequel II/IIe | Nanopore PromethION |
|---|---|---|---|
| {row.category} |
{row.illumina}
|
{formatContent(row.pacbio)}
|
{formatContent(row.nanopore)}
|