// app/rna-sequencing/lncrna-sequencing/components/LncRNAIntroduction.jsx
import IntroductionLayout from '../../../components/shared/IntroductionLayout';

const LncRNAIntroduction = () => {
  const contentItems = [
    "Long non-coding RNAs (lncRNAs) are a class of RNA molecules longer than 200 nucleotides that do not code for proteins. Based on their position and direction of transcription, lncRNAs are further classified into subtypes such as antisense, intergenic, overlapping, intronic, bidirectional, and processed. These RNAs play essential roles in regulating gene expression at various levels, impacting a wide range of cellular processes.",
    "lncRNA sequencing workflow starts with the removal of ribosomal RNA (rRNA) from the total RNA sample to isolate lncRNAs and mRNAs. The isolated RNA is then subjected to library preparation and high-throughput sequencing. Through specific computational pipelines lncRNAs will be identified during bio-informatic analysis.",
    "The bioinformatics pipeline for lncRNA sequencing involves the alignment of sequencing data to reference genomes, identification of lncRNAs, quantification of their expression level, and other downstream analyses.",
    "lncRNA sequencing uncovers their roles in gene regulation and highlights their various functions, including chromatin remodeling, transcriptional control, nucleosome repositioning, and post-transcriptional processing."
  ];
  const advantageItems = [
    "Identifies both well-known and novel lncRNAs, providing fresh insights into their roles and potential as biomarkers.",
    "Reveals lncRNAs' involvement in a broad range of molecular functions, such as chromatin remodeling, which is essential for regulating gene expression. This process includes modifying chromatin structure to control gene accessibility and influencing various cellular mechanisms, demonstrating lncRNAs' crucial roles in gene regulation and cellular function across mammals and plants.",
    "Provides a thorough understanding of lncRNAs' roles in gene regulation, encompassing both transcriptional and post-transcriptional levels. It highlights how lncRNAs affect transcription factors, alter nucleosome positioning, and contribute to RNA splicing and stability, thus impacting overall gene expression and cellular processes.",
    "Enables high-resolution analysis, allowing for precise detection and detailed characterization of lncRNA expression and their regulatory networks, offering a deep dive into their functional roles within cells."
  ];

  return (
    <IntroductionLayout
      introTitle="Introduction and Workflow"
      advantageTitle="Advantage"
      introItems={contentItems}
      advantageItems={advantageItems}
      imageUrl="/images/rna/lncRNA_sequencing.png"
      imageAlt="lncRNA Sequencing Workflow"
      useParagraphs={true}
    />
  );
};

export default LncRNAIntroduction;