// app/dna-sequencing/enrichment-sequencing/whole-exome/components/ExomeIntroduction.jsx

import IntroductionLayout from '../../../../components/shared/IntroductionLayout';

const ExomeIntroduction = () => {
  const contentItems = [
    "Whole Exome Sequencing (WES) is sequencing of only protein-coding regions (<2% of the genome, also known as exome), which accounts for 80-85% of disease-related variants.",
    "The workflow involves DNA isolation, fragmentation, capturing exonic regions, and sequencing to generate millions of short reads. In the bioinformatics analysis, these reads undergo alignment to a reference genome, followed by the variant calling (SNVs, Indels) and data analysis.",
    "Pinpoints potential disease-causing mutations, providing valuable insights for population genetics, genetic disease research, and cancer studies.",
    "Extensively utilized in diagnostic setting to detect clinically relevant genomic alterations associated with phenotype of the patient."
  ];
  const advantageItems = [
    "Cost-effective as compared to Whole Genome Sequencing (WGS), making it accessible to a broader range of researchers and clinicians.",
    "WES offers extensive sequencing of exonic regions, improving the detection of single-nucleotide variants (SNVs), copy number variants (CNVs), and insertions/deletions (InDels) with a sensitivity comparable to WGS, ensuring high accuracy in identifying genetic variants.",
    "WES generates a smaller data set compared to WGS, facilitating faster and easier data analysis, which can expedite research and diagnostic processes.",
    "WES is widely used in both medical and agricultural fields, supporting advancements in disease diagnosis, personalized medicine, and crop improvement. Provides a comprehensive, high-resolution view of the genome, surpassing the coverage offered by targeted sequencing."
  ];

  return (
    <IntroductionLayout
      introTitle="Introduction and Workflow"
      advantageTitle="Advantage"
      introItems={contentItems}
      advantageItems={advantageItems}
      imageUrl="/images/dna/whole_exome_seq_targeted_dna_seq.png"
      imageAlt="DNA Structure"
      useParagraphs={true}
    />
  );
};

export default ExomeIntroduction;