32 lines
2.2 KiB
JavaScript
32 lines
2.2 KiB
JavaScript
// app/dna-sequencing/enrichment-sequencing/whole-exome/components/ExomeIntroduction.jsx
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import IntroductionLayout from '../../../../components/shared/IntroductionLayout';
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const ExomeIntroduction = () => {
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const contentItems = [
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"Whole Exome Sequencing (WES) is sequencing of only protein-coding regions (<2% of the genome, also known as exome), which accounts for 80-85% of disease-related variants.",
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"The workflow involves DNA isolation, fragmentation, capturing exonic regions, and sequencing to generate millions of short reads. In the bioinformatics analysis, these reads undergo alignment to a reference genome, followed by the variant calling (SNVs, Indels) and data analysis.",
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"Pinpoints potential disease-causing mutations, providing valuable insights for population genetics, genetic disease research, and cancer studies.",
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"Extensively utilized in diagnostic setting to detect clinically relevant genomic alterations associated with phenotype of the patient."
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];
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const advantageItems = [
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"Cost-effective as compared to Whole Genome Sequencing (WGS), making it accessible to a broader range of researchers and clinicians.",
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"WES offers extensive sequencing of exonic regions, improving the detection of single-nucleotide variants (SNVs), copy number variants (CNVs), and insertions/deletions (InDels) with a sensitivity comparable to WGS, ensuring high accuracy in identifying genetic variants.",
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"WES generates a smaller data set compared to WGS, facilitating faster and easier data analysis, which can expedite research and diagnostic processes.",
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"WES is widely used in both medical and agricultural fields, supporting advancements in disease diagnosis, personalized medicine, and crop improvement. Provides a comprehensive, high-resolution view of the genome, surpassing the coverage offered by targeted sequencing."
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];
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return (
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<IntroductionLayout
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introTitle="Introduction and Workflow"
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advantageTitle="Advantage"
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introItems={contentItems}
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advantageItems={advantageItems}
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imageUrl="/images/dna/whole_exome_seq_targeted_dna_seq.png"
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imageAlt="DNA Structure"
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useParagraphs={true}
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/>
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);
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};
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export default ExomeIntroduction; |